A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel.

摘要: Despite the fact that seizures are commonly associated with autism spectrum disorder (ASD), effectiveness of treatments for has not been well studied in individuals ASD. This manuscript reviews both traditional and novel Studies were selected by systematically searching major electronic databases a panel experts treat ASD individuals. Only few anti-epileptic drugs (AEDs) have undergone carefully controlled trials ASD, but these examined outcomes other than seizures. Several lines evidence point to valproate, lamotrigine, levetiracetam as most effective tolerable AEDs Limited supports use non-AED treatments, such ketogenic modified Atkins diet, multiple subpial transections, immunomodulation, neurofeedback treatments. Although specific may be more appropriate genetic metabolic syndromes seizures, there studies which documented syndromes. L-carnitine, multivitamins, andN-acetyl-L-cysteine mitochondrial disease dysfunction, folinic acid cerebral folate abnormalities early treatment vigabatrin tuberous sclerosis complex. Finally, is limited number particularly magnesium pyridoxine, omega-3 fatty acids, glutenfree casein-free low-frequency repetitive transcranial magnetic simulation. Zinc L-carnosine potential supported basic research clinical studies. review demonstrates wide variety used striking lack performed support Additional concerning controlling warranted.