Gene Expression Analysis of Circulating Hormone Refractory Prostate Cancer Micrometastases

摘要: Abstract : This annual report for the Physician Research Training Award focuses on progress in genetic analysis of circulating hormone refractory prostate cancer micrometastases. As metastatic tissue is often inaccessible advanced patients, tumor cells may provide understanding biology as well chemotherapy resistance. Oligonucleotide array comparative genomic hybridization allows assessment changes that occur process metastasis and Genomic profiling using this technology will go beyond cell counting, circumvent technical complexities related to working with RNA. Work performed over last year has perfected techniques deal small amounts DNA isolated Vitatex isolation system. Preliminary data suggests reproducible alterations are observed from patients cancer. During 3, having ironed out methodology pursuing work, we ramp up collection peripheral blood chemotherapy-na(ve chemotherapy-refractory isolate perform analyses.