Nuclear Receptors as Drug Targets in Cholestatic Liver Diseases
作者： Emina Halilbasic , Anna Baghdasaryan , Michael Trauner
DOI: 10.1016/J.CLD.2012.12.001
关键词:
摘要: … Several already available drugs may exert their beneficial effects in cholestasis via NR activation (eg, ursodeoxycholic acid via glucocorticoid receptor and pregnane X receptor; …
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Balazs Halmos, Ferenc Szalay, Tamas Cserniczky, Elemer Nemesanszky, Peter Lakatos, Stefan Barlage, Gerd Schmitz, Laszlo Romics, Albert Csaszar, Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population. Digestive Diseases and Sciences. ,vol. 45, pp. 1091- 1095 ,(2000) , 10.1023/A:1005581414918
Francois-Xavier Caroli-Bosc, Philippe Le Gall, Pascal Pugliese, Benoit Delabre, Corinne Caroli-Bosc, Jean-Francois Demarquay, Jean-Pierre Delmont, Patrick Rampal, J.C. Montet, Role of fibrates and HMG-CoA reductase inhibitors in gallstone formation: epidemiological study in an unselected population. Digestive Diseases and Sciences. ,vol. 46, pp. 540- 544 ,(2001) , 10.1023/A:1005643014395
Yasuhito Yamanishi, Yasuo Nosaka, Hironaka Kawasaki, Chisato Hirayama, Shiro Ikawa, Sterol and bile acid metabolism after short-term prednisolone treatment in patients with chronic active hepatitis. Gastroenterologia Japonica. ,vol. 20, pp. 246- 251 ,(1985) , 10.1007/BF02774711
Heather L. McMurtrie, Haley J. Cleary, Bernardo V. Alvarez, Frederick B. Loiselle, Deborah Sterling, Patricio E. Morgan, Danielle E. Johnson, Joseph R. Casey, The bicarbonate transport metabolon Journal of Enzyme Inhibition and Medicinal Chemistry. ,vol. 19, pp. 231- 236 ,(2004) , 10.1080/14756360410001704443
Juan F. Medina, Role of the anion exchanger 2 in the pathogenesis and treatment of primary biliary cirrhosis. Digestive Diseases. ,vol. 29, pp. 103- 112 ,(2011) , 10.1159/000324144
Lee A. Denson, Ekkehard Sturm, Wihelma Echevarria, Tracy L. Zimmerman, Makoto Makishima, David J. Mangelsdorf, Saul J. Karpen, The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology. ,vol. 121, pp. 140- 147 ,(2001) , 10.1053/GAST.2001.25503
J.W. Ding, R. Andersson, V. Soltesz, R. Willén, S. Bengmark, The Role of Bile and Bile Acids in Bacterial Translocation in Obstructive Jaundice in Rats European Surgical Research. ,vol. 25, pp. 11- 19 ,(1993) , 10.1159/000129252
Shuguang Wang, KehDih Lai, Franklin J. Moy, Anitha Bhat, Helen B. Hartman, Mark J. Evans, The Nuclear Hormone Receptor Farnesoid X Receptor (FXR) Is Activated by Androsterone Endocrinology. ,vol. 147, pp. 4025- 4033 ,(2006) , 10.1210/EN.2005-1485
Antonio Moschetta, Angie L Bookout, David J Mangelsdorf, Prevention of cholesterol gallstone disease by FXR agonists in a mouse model Nature Medicine. ,vol. 10, pp. 1352- 1358 ,(2004) , 10.1038/NM1138
Jyrki J. Eloranta, Diana Jung, Gerd A. Kullak-Ublick, The Human Na+-Taurocholate Cotransporting Polypeptide Gene Is Activated by Glucocorticoid Receptor and Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α, and Suppressed by Bile Acids via a Small Heterodimer Partner-Dependent Mechanism Molecular Endocrinology. ,vol. 20, pp. 65- 79 ,(2006) , 10.1210/ME.2005-0159