Statistically identifying an increased risk for disease

作者: Christopher Aston , David Ralph

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摘要: Methods and computer readable media for statistically identifying an increased risk disease. In one embodiment, resampling techniques are utilized to consider different genotype combinations within a subset of case/control data set. Odds-ratios theoretical p-values calculated each combination so that disease associated with particular may be identified. another set aer considered. Odds ratios combination. Empirical the odds through randomization techniques. Using odds-ratios and/or empirical p-values,

参考文章(4)
Daniele Fallin, Annick Cohen, Laurent Essioux, Ilya Chumakov, Marta Blumenfeld, Daniel Cohen, Nicholas J Schork, Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome Research. ,vol. 11, pp. 143- 151 ,(2001) , 10.1101/GR.148401