Methods of dna marker-based genetic analysis using estimated haplotype frequencies and uses thereof

摘要: The present invention is primarily drawn to methods of DNA marker-based genetic analysis using estimated haplotype frequencies draw inferences about the relationship between haplotypes and traits or diseases. Unlike many that require phase information can be difficult obtain from samples non-haploid species, instant are based on strategies for estimating unphased diploid genotype data Estimation-Maximization (E-M) algorithm overcome missing information. These then used in a variety statistical analyses, including those infer existence disease gene. process include: 1) frequencies; 2) computing test statistics; 3) drawing inferences.