Retinal vessel oxygen saturation and vessel diameter in healthy individuals during high-altitude exposure.

摘要: PURPOSE To assess changes of retinal vessel oxygen saturation and diameter in healthy individuals during high-altitude exposure. METHODS Retinal were obtained at sea level (SL, 40 m) high altitude (HA, 3681 m) on 17 from Beijing (six males, 28.06 ± 8.06 years) using Oxymap T1 then compared with 21 residents Yushu (10 28.63 ± 6.00 years). Systemic ocular parameters also measured before after Data presented as mean ± SD analysed paired independent Student t-test significance accepted p < 0.05. RESULTS Short-term exposure Group significantly affected all the systemic parameters, well ranging overall quadrant to different quadrants, other than venous arterial diameter. However, these not evident those permanently living HA. Pearson's correlation analysis revealed correlations between (all p < 0.05). The multivariate linear regression indicated that was associated peripheral (SpO2 ) subfoveal choroidal thickness. CONCLUSION HA induces microcirculation disturbance auto-regulatory response individuals, which is probably attributed SpO2 endothelial dysfunction under hypoxic conditions.