Xenopus as a model for studies in mechanical stress and cell division.

摘要: We exist in a physical world, and cells within biological tissues must respond appropriately to both environmental forces generated the tissue ensure normal development homeostasis. Cell division is required for growth maintenance, but direction rate of cell be tightly controlled avoid diseases over-proliferation such as cancer. Recent studies have shown that mechanical cues can cause mitotic entry orient spindle, suggesting force could play role patterning growth. However, fully understand how mechanics guides vivo, it necessary assess interaction strain whole context. In this mini-review we first summarise body work linking division, before looking at advantages Xenopus embryo offer model organism understanding: 1) environment during embryogenesis, 2) factors important division. Finally, introduce novel method applying reproducible embryonic assessing subsequent divisions. This article protected by copyright. All rights reserved.