Increase of circulating γ/δ T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease
作者： R. GIACOMELLI , I. PARZANESE , G. FRIERI , A. PASSACANTANDO , F. PIZZUTO
DOI: 10.1111/J.1365-2249.1994.TB06611.X
关键词:
摘要: In order to study the role of gamma/delta T cells in pathogenesis inflammatory bowel disease (IBD) humans, we measured percentage these peripheral blood, assessed ratio non-disulphide-linked (delta TCS1) type cell receptor (TCR) total cells, studied co-expression TCR and accessory molecules CD8 CD16, compared data with both activity disease. Percentage levels absolute numbers gamma/delta+ were higher active patients than controls (P < 0.05), mainly as a result an increase V delta 1+ subset 0.05). This trend was strongly retained independently clinical picture. An increased 1+/CD16+ observed our contrast, no difference far 1+/CD8+ concerned. These results suggest that IBD is associated expansion which may play disorders.
sci-hub.se 参考文章(47)
J Markowitz, F Daum, F Mandel, K Grancher, Immunosuppressive therapy in pediatric inflammatory bowel disease: results of a survey of the North American Society for Pediatric Gastroenterology and Nutrition. Subcommittee on Immunosuppressive Use of the Pediatric IBD Collaborative Research Forum. The American Journal of Gastroenterology. ,vol. 88, pp. 44- 48 ,(1993)
Richard P. MacDermott, M.Janice Bragdon, Ira J. Kodner, Michael J. Bertovich, Deficient cell-mediated cytotoxicity and hyporesponsiveness to interferon and mitogenic lectin activation by inflammatory bowel disease peripheral blood and intestinal mononuclear cells. Gastroenterology. ,vol. 90, pp. 6- 11 ,(1986) , 10.1016/0016-5085(86)90067-3
Marc Bonneville, Charles A. Janeway, Kouichi Ito, Wayne Haser, Isao Ishida, Nobuki Nakanishit, Susumu Tonegawa, Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells Nature. ,vol. 336, pp. 479- 481 ,(1988) , 10.1038/336479A0
Roy G. Shorter, Douglas B. McGill, Robert C. Bahn, Cytotoxicity of mononuclear cells for autologous colonic epithelial cells in colonic diseases Gastroenterology. ,vol. 86, pp. 13- 22 ,(1984) , 10.1016/0016-5085(84)90584-5
Philippa Marrack, John Kappler, The antigen-specific, major histocompatibility complex-restricted receptor on T cells. Advances in Immunology. ,vol. 38, pp. 1- 30 ,(1986) , 10.1016/S0065-2776(08)60005-X
J A Bluestone, J C Pena, D Deluca, L Matis, Y Tatsumi, Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation. Journal of Immunology. ,vol. 151, pp. 3030- 3041 ,(1993)
Kazuichi Okazaki, Masanori Morita, Isao Nishimori, Shuichi Sano, Machi Toyonaga, Yoshihiko Nakazawa, Yasuro Yamamoto, Yasutake Yamamoto, Major histocompatibility antigen-restricted cytotoxicity in inflammatory bowel disease. Gastroenterology. ,vol. 104, pp. 384- 391 ,(1993) , 10.1016/0016-5085(93)90405-2
C. Fiocchi, Immune events associated with inflammatory bowel disease. Scandinavian Journal of Gastroenterology. ,vol. 172, pp. 4- 12 ,(1990) , 10.3109/00365529009091902
D V Havlir, J J Ellner, K A Chervenak, W H Boom, Selective expansion of human gamma delta T cells by monocytes infected with live Mycobacterium tuberculosis. Journal of Clinical Investigation. ,vol. 87, pp. 729- 733 ,(1991) , 10.1172/JCI115053
Dominique Dunon, Max D. Cooper, Beat A. Imhof, Migration patterns of thymus‐derived γδ T cells during chicken development European Journal of Immunology. ,vol. 23, pp. 2545- 2550 ,(1993) , 10.1002/EJI.1830231025