Radiolabeled Nanogels for Nuclear Molecular Imaging
作者： Smriti Singh , Bahar Bingöl , Agnieszka Morgenroth , Felix M. Mottaghy , Martin Möller
关键词:
摘要: An efficient and simple synthesis approach to form stable (68) Ga-labeled nanogels is reported their fundamental properties investigated. Nanogels are obtained by self-assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting exhibit a well-defined spherical shape diameter 290 +/- 50 nm. radionuclide Ga chelated in high radiochemical yields an aqueous medium at room temperature. phagocytosis assay demonstrates highly increased internalization activated macrophages. Access these Ga-nanogels will allow the investigation general behavior clearance pathways vivo nuclear molecular imaging.
core.ac.uk
narcis.nl参考文章(20)
Yasuhiro Matsumura, Hiroshi Maeda, A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs Cancer Research. ,vol. 46, pp. 6387- 6392 ,(1986)
Mareli Allmeroth, Dorothea Moderegger, Barbara Biesalski, Kaloian Koynov, Frank Rösch, Oliver Thews, Rudolf Zentel, Modifying the Body Distribution of HPMA-Based Copolymers by Molecular Weight and Aggregate Formation Biomacromolecules. ,vol. 12, pp. 2841- 2849 ,(2011) , 10.1021/BM2005774
Juergen Groll, Smriti Singh, Krystyna Albrecht, Martin Moeller, Biocompatible and degradable nanogels via oxidation reactions of synthetic thiomers in inverse miniemulsion Journal of Polymer Science Part A. ,vol. 47, pp. 5543- 5549 ,(2009) , 10.1002/POLA.23595
Julie Thevenot, Anne-Lise Troutier, Laurent David, Thierry Delair, Catherine Ladavière, Steric Stabilization of Lipid/Polymer Particle Assemblies by Poly(ethylene glycol)-Lipids Biomacromolecules. ,vol. 8, pp. 3651- 3660 ,(2007) , 10.1021/BM700753Q
Akihito Hashidzume, Atsushi Kawaguchi, Akiyo Tagawa, Katsuhiro Hyoda, Takahiro Sato, Synthesis and Structural Analysis of Self-Associating Amphiphilic Statistical Copolymers in Aqueous Media Macromolecules. ,vol. 39, pp. 1135- 1143 ,(2006) , 10.1021/MA051950D
Xiankai Sun, Raffaella Rossin, Jeffrey L. Turner, Matthew L. Becker, Maisie J. Joralemon, Michael J. Welch, Karen L. Wooley, An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. Biomacromolecules. ,vol. 6, pp. 2541- 2554 ,(2005) , 10.1021/BM050260E
R Gref, Y Minamitake, M. Peracchia, V Trubetskoy, V Torchilin, R Langer, Biodegradable long-circulating polymeric nanospheres Science. ,vol. 263, pp. 1600- 1603 ,(1994) , 10.1126/SCIENCE.8128245
Ruth Duncan, The dawning era of polymer therapeutics Nature Reviews Drug Discovery. ,vol. 2, pp. 347- 360 ,(2003) , 10.1038/NRD1088
Sheetal Soni, Anil k Babbar, Rakesh k Sharma, Amarnath Maitra, None, Delivery of hydrophobised 5-fluorouracil derivative to brain tissue through intravenous route using surface modified nanogels. Journal of Drug Targeting. ,vol. 14, pp. 87- 95 ,(2006) , 10.1080/10611860600635608
M. Fani, L. Del Pozzo, K. Abiraj, R. Mansi, M. L. Tamma, R. Cescato, B. Waser, W. A. Weber, J. C. Reubi, H. R. Maecke, PET of Somatostatin Receptor–Positive Tumors Using 64Cu- and 68Ga-Somatostatin Antagonists: The Chelate Makes the Difference The Journal of Nuclear Medicine. ,vol. 52, pp. 1110- 1118 ,(2011) , 10.2967/JNUMED.111.087999