Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats.

摘要: The health impact of dust events from China has become a concern within and in its neighboring countries. Previous epidemiological studies have demonstrated an association between particulate matter exposure cardiopulmonary mortality. Here, we use pulmonary hypertensive rat models to examine inflammation markers the lung peripheral blood after Asian storm particles. Using nose-only inhalation system, eight rats were exposed concentrated ambient particles (CAPs) actual that took place March 18 19, 2002; four control also room air. Four CAPs 315.6 g/m3 for 6 h classified as low-exposure group, another 684.5 4.5 high-exposure group. animals sacrificed 36 exposure. Inflammation bronchoalveolar lavage (BAL) analyzed, IL-6 BAL was determined using ELISA. White cell counts increased with CAP levels (P<0.001, test trend). In analysis, total numbers proportion neutrophil trend both markers). Positive dose-response relationships protein (P<0.05) LDH activity observed. Moreover, increasing (P<0.05, trend) demonstrated. Our results revealed matters during could increase injury rats. Further are needed determine components may contribute particle toxicity.