Myeloid dendritic cells in HIV-1 infection.

摘要: Purpose of review—Myeloid dendritic cells (mDCs) are pivotal players in HIV-1 infection. They promote transmission and spread at the same time critical for recognizing initiating immune responses to fight Notably, their immunostimulatory capabilities can be harnessed design better vaccines. In this review, advances these areas mDCHIV-1 interactions summarized. Recent findings—New insights into HIV-1-induced dysfunction mDCs dysfunctional mDC effects on other cell types, as well novel mechanisms viral sensing by evasion have been uncovered. These results emphasize importance protection against Targeting with vaccines tailored adjuvants may improve quality anatomical location elicited responses. Summary—Understanding multiplicity HIV-1-DC together numerous targeted therapy vaccination will help rational approaches treat block