A Tonsillar PolyICLC/AT-2 SIV Therapeutic Vaccine Maintains Low Viremia Following Antiretroviral Therapy Cessation
作者： Panagiotis Vagenas , Meropi Aravantinou , Vennansha G. Williams , Edith Jasny , Michael Piatak
DOI: 10.1371/JOURNAL.PONE.0012891
关键词:
摘要: Background HIV-infected individuals rely on antiretroviral therapy (ART) to control viral replication. Despite abundant demonstrable benefits, the multiple limitations of ART point potential advantages therapeutic vaccination approaches that could provide sustained host replication after discontinuation ART. We evidence from a non-human primate model vaccine applied tonsils can maintain low loads cessation
paperity.org
core.ac.uk 参考文章(66)
Mark P. Eggena, Banson Barugahare, Norman Jones, Martin Okello, Steven Mutalya, Cissy Kityo, Peter Mugyenyi, Huyen Cao, Depletion of Regulatory T Cells in HIV Infection Is Associated with Immune Activation The Journal of Immunology. ,vol. 174, pp. 4407- 4414 ,(2005) , 10.4049/JIMMUNOL.174.7.4407
Y. Ishida, Y. Agata, K. Shibahara, T. Honjo, Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. The EMBO Journal. ,vol. 11, pp. 3887- 3895 ,(1992) , 10.1002/J.1460-2075.1992.TB05481.X
Adam C Finnefrock, Aimin Tang, Fengsheng Li, Daniel C Freed, Meizhen Feng, Kara S Cox, Kara J Sykes, James P Guare, Michael D Miller, David B Olsen, Daria J Hazuda, John W Shiver, Danilo R Casimiro, Tong-Ming Fu, None, PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination Journal of Immunology. ,vol. 182, pp. 980- 987 ,(2009) , 10.4049/JIMMUNOL.182.2.980
P A Marx, C J Miller, N J Alexander, S Sutjipto, A A Lackner, A Gettie, A G Hendrickx, L J Lowenstine, M Jennings, Genital mucosal transmission of simian immunodeficiency virus: animal model for heterosexual transmission of human immunodeficiency virus. Journal of Virology. ,vol. 63, pp. 4277- 4284 ,(1989) , 10.1128/JVI.63.10.4277-4284.1989
Nadine C. Salisch, Daniel E. Kaufmann, Amany S. Awad, R. Keith Reeves, Daniel P. Tighe, Yuan Li, Michael Piatak, Jeffrey D. Lifson, David T. Evans, Florencia Pereyra, Gordon J. Freeman, R. Paul Johnson, Inhibitory TCR Coreceptor PD-1 Is a Sensitive Indicator of Low-Level Replication of SIV and HIV-1 Journal of Immunology. ,vol. 184, pp. 476- 487 ,(2010) , 10.4049/JIMMUNOL.0902781
David T. Evans, David H. O'Connor, Peicheng Jing, John L. Dzuris, John Sidney, Jack da Silva, Todd M. Allen, Helen Horton, John E. Venham, Richard A. Rudersdorf, Thorsten Vogel, C. David Pauza, Ronald E. Bontrop, Robert DeMars, Alessandro Sette, Austin L. Hughes, David I. Watkins, Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nature Medicine. ,vol. 5, pp. 1270- 1276 ,(1999) , 10.1038/15224
G. M. Ortiz, M. Wellons, J. Brancato, H. T. T. Vo, R. L. Zinn, D. E. Clarkson, K. Van Loon, S. Bonhoeffer, G. D. Miralles, D. Montefiori, J. A. Bartlett, D. F. Nixon, Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 13288- 13293 ,(2001) , 10.1073/PNAS.221452198
Rachmat Hidajat, Peng Xiao, Qifeng Zhou, David Venzon, L. Ebonita Summers, Vaniambadi S. Kalyanaraman, David C. Montefiori, Marjorie Robert-Guroff, Correlation of Vaccine-Elicited Systemic and Mucosal Nonneutralizing Antibody Activities with Reduced Acute Viremia following Intrarectal Simian Immunodeficiency Virus SIVmac251 Challenge of Rhesus Macaques Journal of Virology. ,vol. 83, pp. 791- 801 ,(2009) , 10.1128/JVI.01672-08
I. Frank, M. Piatak, H. Stoessel, N. Romani, D. Bonnyay, J.D. Lifson, M. Pope, Infectious and Whole Inactivated Simian Immunodeficiency Viruses Interact Similarly with Primate Dendritic Cells (DCs): Differential Intracellular Fate of Virions in Mature and Immature DCs Journal of Virology. ,vol. 76, pp. 2936- 2951 ,(2002) , 10.1128/JVI.76.6.2936-2951.2002
Muhamuda Kader, Wail M. Hassan, Matthew Eberly, Michael Piatak, Jeffrey D. Lifson, Mario Roederer, Joseph J. Mattapallil, Antiretroviral Therapy prior to Acute Viral Replication Preserves CD4 T Cells in the Periphery but Not in Rectal Mucosa during Acute Simian Immunodeficiency Virus Infection Journal of Virology. ,vol. 82, pp. 11467- 11471 ,(2008) , 10.1128/JVI.01143-08