Relationship between T cell subpopulations and the mitogen responsiveness and suppressor cell function of peripheral blood mononuclear cells in normal individuals.

摘要: A simultaneous analysis was made of numbers and proportions T cell subsets (T mu gamma cells), lymphocyte responsiveness to non-specific mitogens in vitro 'short-lived suppressor activity' peripheral blood mononuclear cells (PBMC) normal individuals. No correlation found between either or the activity', suggesting that suppression this system is not a reflection quantitative alteration these subsets. However, highly significant positive PBMC responses phytohaemagglutinin, concanavalin pokeweek mitogen. This may reflect helper effect on proliferation response presence majority mitogen-responsive within subpopulation. As individuals correlates with number circulating cells, it possible reduction disease states contribute defects cell-mediated immunity.