In VitroBiomimetic Model of the Human Immune System for Predictive Vaccine Assessments
作者： Donald R. Drake , Inderpal Singh , Michael N. Nguyen , Anatoly Kachurin , Vaughan Wittman
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摘要: Abstract Video The development of vaccines and immunotherapeutics is hampered by the lack appropriate in vitro assays which to test these compounds against human immune system. By recognizing key cellular elements (concentration types cells, cell motility, media, multicellular interactions, spatiotemporal kinetics, expansion, geometries) tissues, such as lymph node, we believed that could recapitulate function a biomimetic model system, termed Modular Immune In Construct (MIMIC®). We describe here process undertook develop MIMIC system considering engineering design principles, selection cells populate functionality, new antibody assays, tissue construct automation. also our approach toward using relevant challenges, influenza, exemplars different facets immunity validate Through evaluating ...
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