Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients

摘要: The consequence of the mutations in CFTR gene is malfunction chloride channel cystic fibrosis (CF) patients, which leads to decreased volume paraciliary fluid lower respiratory tract, and that turn impaired mucociliary clearance inhaled microbes (Boucher 2004). This impairment non-inflammatory defense mechanism tract early recruitment inflammatory mechanisms, e.g., polymorphonuclear leukocytes (PMN) antibodies (Armstrong et al. 1995, 2005, Hoiby 2001). CF therefore, from childhood suffer recurrent chronic infections characterized by PMN inflammation.