Health-related quality of life in patients with high-grade gliomas: a quantitative longitudinal study

摘要: The diagnosis of a high-grade glioma usual is followed by functional impairment(s), cognitive decline and an impaired psycho-social well-being. This might well have significant negative impact on the health related quality life. purpose this study was to explore physical activity levels, prevalence severity anxiety depressive symptoms health-related life among patients with highgrade glioma. paper based longitudinal mixed methods study. Patients (n = 30) completed questionnaires at 5 time points from until final follow-up after 1 year. Scores Karnofsky Performance Status (KPS), activity, depression (FACT-Br) are obtained. Patients’ level KPS decrease during disease- treatment trajectory. majority did not report any symptoms, eight individuals (26.7 %) being depressed various points. Among sub-group participants who all requirements for entire period decreased significantly FACT-Br sub-scale emotional well-being increased significant, indicating better HRQOL attend followup. HGG leads ongoing measured as reduced leisure time. Supportive care combined rehabilitative palliative approaches be valuable along trajectory especially post-surgery when its highest peak.