Synthesis of Monomeric and Dimeric Acridine Compounds as Potential Therapeutics in Alzheimer and Prion Diseases
作者： René Csuk , Alexander Barthel , Christian Raschke , Ralph Kluge , Dieter Ströhl
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摘要: Starting from substituted 9-chloroacridines, a series of quinacrine and spacered dimeric acridine compounds was prepared. Their ability to interrupt the protein association prion- Alzheimer-specific proteins Ab peptides explored using fast screening system based on FACS analysis. The bis-acridines displayed higher activity than corresponding monomers. Among these derivatives, best results were obtained with 2,4-dimethoxy-6-nitro compound 7h for Abeta-peptides 2-methoxy-6-nitro 7f PrP.
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