Stability of heroin hydrochloride in infusion devices and containers for intravenous administration

摘要: The stability of heroin hydrochloride in various drug-administration devices was studied. Heroin supplied as the bulk powder by National Institute on Drug Abuse and formulated dosage form Evans Medical, Ltd. Stability determined at concentrations 1 20 mg/mL room temperature (23-25 degrees C) 4 C a polyvinyl chloride (PVC) bag, disposable glass syringe, two infusion devices. Studies both also were conducted 31 All experiments triplicate. A validated, stability-indicating, high-performance liquid chromatography assay used. remained stable for minimum 15 days PVC bag Infusor device tested temperatures concentrations. In shown to be if refrigerated C, whereas it 7 12 mg/mL. Intermate 200 device, all except concentration C. latter case, days. No substantial changes physical appearance or pH observed any containers under conditions can repackaged each routine clinical use.