Mechanisms and dynamics of nuclear lamina-genome interactions.
作者： Mario Amendola , Bas van Steensel
DOI: 10.1016/J.CEB.2014.03.003
关键词:
摘要: The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization gene expression. Both sequences histone modifications are important for NL tethering of DNA. These interactions dynamic in individual cells can change during differentiation development. Evidence accumulating that contributes repression transcription. Advances mapping, genome-editing microscopy techniques increasing our understanding molecular mechanisms involved NL-genome interactions.
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