摘要: The Phase III clinical trial is a randomized, comparative, often multi-institutional study addressed to quantitative question. It the cadillac of trials. When properly applied, it highly effective in comparing new treatment and standard (control) therapy.
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Early Breast Cancer Trialist's Collaborative Group, Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Early Breast Cancer Trialists' Collaborative Group. The Lancet. ,(1992) , 10.1016/0140-6736(92)90997-H
A. GOLDIN, J. M. VENDITTI, S. R. HUMPHREYS, N. MANTEL, Influence of the concentration of leukemic inoculum on the effectiveness of treatment. Science. ,vol. 123, pp. 840- 840 ,(1956) , 10.1126/SCIENCE.123.3202.840
Stephen K. Carter, Adjuvant chemotherapy of cancer. A review of its current status. Drugs. ,vol. 31, pp. 337- 367 ,(1986) , 10.2165/00003495-198631040-00004
Allen M. Goorin, Herbert T. Abelson, Emil Frei, Osteosarcoma: Fifteen Years Later New England Journal of Medicine. ,vol. 313, pp. 1637- 1643 ,(1985) , 10.1056/NEJM198512263132605
William C. Wood, Daniel R. Budman, Ann H. Korzun, M. Robert Cooper, Jerry Younger, Ronald D. Hart, Anne Moore, John A. Ellerton, Larry Norton, Carolyn R. Ferree, Anita Colangelo Ballow, Emil Frei, I. Craig Henderson, Dose and Dose Intensity of Adjuvant Chemotherapy for Stage II, Node-Positive Breast Carcinoma The New England Journal of Medicine. ,vol. 330, pp. 1253- 1259 ,(1994) , 10.1056/NEJM199405053301801
Richard I. Fisher, Ellen R. Gaynor, Steve Dahlberg, Martin M. Oken, Thomas M. Grogan, Evonne M. Mize, John H. Glick, Charles A. Coltman, Thomas P. Miller, Comparison of a Standard Regimen (CHOP) with Three Intensive Chemotherapy Regimens for Advanced Non-Hodgkin's Lymphoma The New England Journal of Medicine. ,vol. 328, pp. 1002- 1006 ,(1993) , 10.1056/NEJM199304083281404
Gianni Bonadonna, Ercole Brusamolino, Pinuccia Valagussa, Anna Rossi, Luisa Brugnatelli, Cristina Brambilla, Mario De Lena, Gabriele Tancini, Emilio Bajetta, Renato Musumeci, Umberto Veronesi, Combination Chemotherapy as an Adjuvant Treatment in Operable Breast Cancer The New England Journal of Medicine. ,vol. 294, pp. 405- 410 ,(1976) , 10.1056/NEJM197602192940801
E Frei, E J Freireich, The clinical cancer researcher--still an embattled species. Journal of Clinical Oncology. ,vol. 11, pp. 1639- 1651 ,(1993) , 10.1200/JCO.1993.11.9.1639