Review: the central role of calcium in the pathogenesis of cardiovascular disease.

摘要: Calcium-dependent processes play a central role in several different cells of the cardiovascular system including vascular smooth muscle and endothelial also monocytes, macrophages platelets. In response to extracellular stimuli cytosolic calcium concentration increases. The increase is composed two distinct phases. Firstly, released from intracellular stores via IP3. second phase influx across cell membrane mostly responsible for sustained rise concentration. This peak prerequisite activation contraction nuclear transcription factors protein biosynthesis. Under ischemic conditions regulatory systems which control free consume major portion cell's physiological energy supply (90%) decreased oxygen under rapidly reduces capacity storage or outward transport its membrane. Calcium antagonist drugs principally act on L-type channels reduce into body. Since are able influence wide range cellular have been implicated atherosclerosis, glomeruloscierosis, left ventricular hypertrophy insulin resistance there strong grounds their use clinical disease states.