Survival after recurrence of Ewing tumors: the St Jude Children's Research Hospital experience, 1979-1999.

摘要: BACKGROUND Despite improved therapies, 30–40% of patients with Ewing tumors (ET) experience recurrence and have a poor prognosis. The authors analyzed factors prognostic survival in recurrent ET. METHODS The assessed the relation between postrecurrence (PRS) demographic, disease, treatment 71 who experienced ET after on one three consecutive institutional protocols. RESULTS Thirty-four (47.9%) had distant recurrence, 25 (35.2%) local 12 (16.9%) both at median 1.7 years diagnosis. probability 5-year PRS (± 1 standard error) was 17.7% ± 4.5%. Recurrence ≥ 2 diagnosis predicted significantly better outcome (5-year PRS, 34.9% 8.5%) compared earlier (5.0% 2.8%; P < 0.001). Patients fared worse 12.5% 8.3%) alone (21.7% 7.8%) or (17.6 6.1%). Among alone, those underwent salvage radical surgery higher estimates (31.4% 11.6%) other (9.1% 6.1%; = 0.023). Pulmonary irradiation outcomes isolated pulmonary estimate, 30.3% vs. 16.7% 10.8%, respectively; 0.018). CONCLUSIONS Although are generally ET, certain patient groups differ appreciably their likelihood survival. that can be treated intensive chemotherapy most favorable outcomes. Cancer 2002;94:561–9. © 2002 American Society.