Molecular chaperones in the brain endothelial barrier: neurotoxicity or neuroprotection?
作者： Dominique Thuringer , Carmen Garrido
关键词:
摘要: Brain microvascular endothelial cells (BMECs) interact with astrocytes and pericytes to form the blood-brain barrier (BBB). Their compromised function alters BBB integrity, which is associated early events in pathogenesis of cancer, neurodegenerative diseases, epilepsy. Interestingly, these conditions also induce expression heat shock proteins (HSPs). Here we review contribution major HSP families BMEC function. Although investigators mainly report protective effects HSPs brain, contrasted results were obtained BMEC, depend both on its location, intra- or extracellular. The therapeutic potential must be scrupulously analyzed before targeting them patients reduce progression brain lesions improve neurologic outcomes long term.-Thuringer, D., Garrido, C. Molecular chaperones barrier: neurotoxicity neuroprotection?
fasebj.org 参考文章(170)
Nobuyuki Yamagishi, Keiichi Ishihara, Youhei Saito, Takumi Hatayama, Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax to mitochondria in HeLa cells Experimental Cell Research. ,vol. 312, pp. 3215- 3223 ,(2006) , 10.1016/J.YEXCR.2006.06.007
Ibolya Horváth, Gabriele Multhoff, Alois Sonnleitner, László Vígh, None, Membrane-associated stress proteins: More than simply chaperones Biochimica et Biophysica Acta. ,vol. 1778, pp. 1653- 1664 ,(2008) , 10.1016/J.BBAMEM.2008.02.012
S. Lehnardt, E. Schott, T. Trimbuch, D. Laubisch, C. Krueger, G. Wulczyn, R. Nitsch, J. R. Weber, A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS The Journal of Neuroscience. ,vol. 28, pp. 2320- 2331 ,(2008) , 10.1523/JNEUROSCI.4760-07.2008
W. Luo, F. Dou, A. Rodina, S. Chip, J. Kim, Q. Zhao, K. Moulick, J. Aguirre, N. Wu, P. Greengard, G. Chiosis, Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 9511- 9516 ,(2007) , 10.1073/PNAS.0701055104
T Borovski, P Beke, O van Tellingen, H M Rodermond, J J Verhoeff, V Lascano, J B Daalhuisen, J P Medema, M R Sprick, Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme. Oncogene. ,vol. 32, pp. 1539- 1548 ,(2013) , 10.1038/ONC.2012.172
Paolo Aridon, Fabiana Geraci, Giuseppina Turturici, Marco D’Amelio, Giovanni Savettieri, Gabriella Sconzo, Protective Role of Heat Shock Proteins in Parkinson’s Disease Neurodegenerative Diseases. ,vol. 8, pp. 155- 168 ,(2011) , 10.1159/000321548
G. P. Lotz, A. Brychzy, S. Heinz, W. M. J. Obermann, A novel HSP90 chaperone complex regulates intracellular vesicle transport. Journal of Cell Science. ,vol. 121, pp. 717- 723 ,(2008) , 10.1242/JCS.015610
Giuseppina Turturici, Gabriella Sconzo, Fabiana Geraci, Hsp70 and Its Molecular Role in Nervous System Diseases Biochemistry Research International. ,vol. 2011, pp. 618127- 618127 ,(2011) , 10.1155/2011/618127
Dongmei Zhang, Linlin Sun, Haiyan Zhu, Lan Wang, Weicheng Wu, Jianhui Xie, Jianxin Gu, Microglial LOX-1 reacts with extracellular HSP60 to bridge neuroinflammation and neurotoxicity Neurochemistry International. ,vol. 61, pp. 1021- 1035 ,(2012) , 10.1016/J.NEUINT.2012.07.019
Binnur Eroglu, Donald E. Kimbler, Junfeng Pang, Justin Choi, Demetrius Moskophidis, Nathan Yanasak, Krishnan M. Dhandapani, Nahid F. Mivechi, Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury Journal of Neurochemistry. ,vol. 130, pp. 626- 641 ,(2014) , 10.1111/JNC.12781