Comparative efficacy and safety of celecoxib and naproxen in the treatment of osteoarthritis of the hip.

摘要: Osteoarthritis (OA) is responsible for more disability of the lower extremities in elderly than any other disease US. The pain associated with OA primary symptom leading to these patients. Current ACR guidelines recommend consideration acetaminophen mild-to-moderate and conventional non-steroidal anti-inflammatory drugs (NSAIDs) or COX-2 specific inhibitors moderate-to-severe symptoms. aim this study was compare efficacy safety COX-1 sparing, inhibitor, celecoxib, NSAID naproxen, placebo, treatment hip. In multicenter, randomized, placebo-controlled trial, 1061 patients symptomatic hip were randomized receive celecoxib at doses 100 mg, 200 400 mg/day; naproxen 1000 12 weeks. Patients evaluated using standard measures baseline, 2–4 days after discontinuing previous analgesic therapy, and...