Continuous smoking and progression of arterial stiffening: a prospective study.

摘要: Objectives We prospectively and longitudinally determined the effects of smoking on progression arterial stiffening as well involvement inflammation in this process. Background Smoking is an important avoidable risk factor for cardiovascular disease, stiffness might be involved pathophysiology. No prospective study has examined effect continuous age-associated stiffening. Methods In 2,054 Japanese subjects (40 ± 8 years age), brachial-ankle pulse wave velocity (baPWV) serum C-reactive protein (CRP) levels were measured at baseline end a 5- to 6-year follow-up period. Results The annual rate change baPWV during period was significantly greater heavy smokers (11.0 1.9 cm/s/year, n = 181) than never-smokers (5.5 0.6 1,018). This difference remained significant even after adjustments covariates, including age (p Conclusions Continuous accelerate structural large- middle-size arteries. also found dose–response relationship between cigarette consumption accelerated However, we failed confirm any association CRP smokers.