Mature neurons: equipped for survival

摘要: Neurons completely transform how they regulate cell death over the course of their lifetimes. Developing neurons freely activate pathways to fine-tune number that are needed during precise formation neural networks. However, regulatory balance between life and shifts as mature beyond early development. Mature promote survival at all costs by employing multiple, often redundant, strategies prevent apoptosis. This dramatic shift from permitting ensuring cellular is critical, these post-mitotic cells must provide neuronal circuitry for an organism's entire lifetime. Importantly, many neurodegenerative diseases afflict adult populations, mechanisms in likely be either reversed or circumvented neurodegeneration. Examining adaptations inhibiting apoptosis maturation key comprehending not just survive long term, but may also insight understanding toxicity various ultimately lead death.