Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer
作者： L Tam , L M McGlynn , P Traynor , R Mukherjee , J M S Bartlett
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摘要: The main cause of prostate cancer-related mortality is the development hormone-refractory disease. Circulating serum levels IL-6 are raised in cancer patients and evidence from cell line studies suggests that IL-6R/JAK/STAT3 pathway may be involved this In current study we investigate if expression these family members implicated cancer. Immunohistochemistry using IL-6R, JAK1, STAT3, pSTAT3Tyr705 pSTAT3Ser727 antibodies was performed on 50 matched hormone-sensitive tumours pairs. An increase cytoplasmic receptor, with associated reduced time to relapse (P=0.0074) while an patient survival (P=0.0003). addition, those high their had significantly shorter death biochemical overall comparison low (P=0.002 P=0.0027, respectively). Activation via phosphorylation survival, suggesting activation
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Leight Gs, Flowers Jl, Soper Jt, McCarty Ks, Cox Eb, Konrath J, Miller L, Creasman Wt, Budwit Da, Szabo E, Use of a Monoclonal Anti-Estrogen Receptor Antibody in the Immunohistochemical Evaluation of Human Tumors Cancer Research. ,vol. 46, ,(1986)
Wolfgang Horninger, Alfred Hobisch, Thomas Putz, Iris E. Eder, Georg Bartsch, Helmut Klocker, Zoran Culig, Interleukin-6 Regulates Prostate-specific Protein Expression in Prostate Carcinoma Cells by Activation of the Androgen Receptor Cancer Research. ,vol. 58, pp. 4640- 4645 ,(1998)
J.E. Nesbitt, G.M. Fuller, Dynamics of interleukin-6 internalization and degradation in rat hepatocytes Journal of Biological Chemistry. ,vol. 267, pp. 5739- 5742 ,(1992) , 10.1016/S0021-9258(18)42613-0
Porn-ngarm Limtrakul, Songyot Anuchapreeda, Suwiwek Lipigorngoson, Floyd W Dunn, None, Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin BMC Cancer. ,vol. 1, pp. 1- 7 ,(2001) , 10.1186/1471-2407-1-1
Li Jia, Catherine S-Y. Choong, Carmela Ricciardelli, Joshua Kim, Wayne D. Tilley, Gerhard A Coetzee, Androgen Receptor Signaling Cancer Research. ,vol. 64, pp. 2619- 2626 ,(2004) , 10.1158/0008-5472.CAN-03-3486
Takeshi Ueda, Nicholas Bruchovsky, Marianne D. Sadar, Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways Journal of Biological Chemistry. ,vol. 277, pp. 7076- 7085 ,(2002) , 10.1074/JBC.M108255200
J BRISCOE, F KOHLHUBER, M MULLERZ, JAKs and STATs branch out Trends in Cell Biology. ,vol. 6, pp. 336- 340 ,(1996) , 10.1016/0962-8924(96)10028-3
Darrel E. Drachenberg, Abdel-Aziz A. Elgamal, Ron Rowbotham, Mary Peterson, Gerald P. Murphy, Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. The Prostate. ,vol. 41, pp. 127- 133 ,(1999) , 10.1002/(SICI)1097-0045(19991001)41:2<127::AID-PROS7>3.0.CO;2-H
Soo Ok Lee, Wei Lou, Candace S. Johnson, Donald L. Trump, Allen C. Gao, Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway The Prostate. ,vol. 60, pp. 178- 186 ,(2004) , 10.1002/PROS.20045
Tetsuya Yamamoto, Noriko Sato, Yuichi Sekine, Taro Yumioka, Seiyu Imoto, Akira Junicho, Hideki Fuse, Tadashi Matsuda, Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor. Biochemical and Biophysical Research Communications. ,vol. 306, pp. 610- 615 ,(2003) , 10.1016/S0006-291X(03)01026-X