Association between clinical characteristics and risk-reduction interventions in women who underwent BRCA1 and BRCA2 testing: a single-institution study.

摘要: BACKGROUND. Women who are at increased risk for breast and ovarian cancers, especially BRCA1 BRCA2 mutation carriers, face a myriad of risk-reduction options, including surveillance, chemoprevention, prophylactic oophorectomy, mastectomy. However, little is known about which clinical, demographic, or cancer-related factors associated with interventions. METHODS. The authors conducted retrospective review records 554 women had undergone testing The University Texas M. D. Anderson Cancer Center between 2000 2006 deleterious gene mutations. Data were collected on the interventions these adopted after they underwent genetic testing. These data tested associations demographic clinical characteristics. RESULTS. Among BRCA mutation, 78 found to have in gene, 54 2 gene. Of women, 85 mastectomy, 30 52 both surgeries; 387 opted surveillance. Women mutations, history cancer ductal carcinoma situ (DCIS), previous biopsies more likely surgery. family undergo oophorectomy. personal advanced surveillance only. total mastectomy as part their prior treatment frequently than either breast-conserving surgery no cancer. In multivariate analysis, only positive carrier status was having addition, significantly mastectomy. CONCLUSIONS. Women cancer, DCIS, biopsy, reduction. 2006. © American Society.