Entry of Mycobacterium tuberculosis into Mononuclear Phagocytes

摘要: Mycobacterium tuberculosis is one of a diverse group intracellular pathogens that survives the process entry into mammalian cells. Multiplication within cell critical for pathogenesis disease by these host-adapted microbes. For M. tuberculosis, major host reservoir mononuclear phagocyte, including both monocytes and macrophages. These cells, along with polymorphonuclear leukocytes, are considered professional phagocytes in they have adapted specifically to engulf destroy bacteria or other foreign particulate matter. Given potent microbiocidal mechanisms cells possess, has strategies circumvent adverse cellular responses during after entry. The earliest interaction between phagocyte binding bacterium surface subsequent internalization. Specific receptor-ligand interactions mediate this internalization outcome may be different than another (Fig. 1). example, it can only attachment bacterium, which less important pathogenesis, ingestion (phagocytosis), turn lead either survival death bacterium. Recent studies provide evidence importance specific pathways (single multiple) cooperativity receptors dictating fate phagocytosed (Joiner et al. 1990; Mosser Edelson 1987; Drevets 1992; Hoepelman Tuomanen Hieny 1992).