Development of a mechanistic model of liver metabolism in the lactating cow

摘要: Abstract In order to accurately predict nutrient requirements and utilization in ruminants, an assessment of hepatic must be made. A mechanistic, dynamic, deterministic model liver metabolism was constructed integrate available data toward this end. The objective the modeling exercise develop a mechanistic ruminant metabolism, based on known metabolic pathways, which capable predicting whole-organ simulating 14C-radiotracer kinetics. program written Advanced Continuous Simulation Language run VAX computer. fourth-order Runge-Kutta procedure used for numerical integration. Development kinetic arguments subsequent parametrization relied heavily in-vivo input: output underlying biochemistry. evaluated using combination behavioral analyses, sensitivity challenges from independent sets.