Metabolic Compartmentation of the Glutamate - Glutamine System: Glial Contribution

摘要: In the two previous symposia on Metabolic Compartmentation in Brain (Balazs and Cremer, 1973; Berl et al., 1975) it had been suggested by several of participants that pools glutamate related metabolites revealed use labelled tracers are probably localized different cell types, namely neurons glia. The nerve endings were as a possible third compartment although model they included with dendrites. has relatively successful fitting most experimental data because focus relationship to glutamine metabolism. Since do not appear be particularly active formation their consideration separate pool could neglected interpretation data. However, when GABA from variety precursors such acetate (Berl 1970), glucose (Gaitonde, 1965; Cremer 1973) 1961; Shank Aprison, 1977) well location decarboxylase (Saito 1974) is considered evident for required.