Composite scaffolds for controlled drug release: Role of the polyurethane nanoparticles on the physical properties and cell behaviour

摘要: Localised delivery of appropriate biomolecule/drug(s) can be suitable to prevent postoperative infections and inflammation after scaffold implantation in vivo. In this study composite shell scaffolds, based on an internally produced bioactive glass a commercial hydroxyapatite, were surface coated with uniform polymeric layer, embedded thermo-stable polyesterurethane (PU)-based nanoparticles (NPs), containing anti-inflammatory drug (indomethacin; IDCM). The obtained functionalised scaffolds subjected physico-mechanical biological characterisations. results indicated that NPs incorporation into the gelatin coating scaffolds: 1) not changed significantly micro-architecture terms mean pore diameter size distribution; 2) increased compressive modulus; 3) allowed sustained IDMC release (65-70% loaded-drug) within first week incubation physiological solution. On other hand, did affect biocompatibility as evidenced by viability alkaline phosphatase (ALP) activity MG63 human osteoblast-like cells.