Determination of photostability and photodegradation products of indomethacin in aqueous media
作者： Fabio Temussi , Flavio Cermola , Marina DellaGreca , M. Rosaria Iesce , Monica Passananti
DOI: 10.1016/J.JPBA.2011.07.005
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摘要: a b s t r c Photochemical behaviour of indomethacin in aqueous media at 254 nm, 310 nm and sunlight was studied by HPLC. The drug exhibited similar all the irradiation experiments affording eight photoproducts that were separated identified. main photochemical routes are suggested to proceed via decarboxylation, followed oxygenation give an alcohol aldehyde and/or solvent trapping produce alcohol. Photoinduced hydrolysis CO–N bond oxidative C2–C3 breakage also occur.
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