Photoproducts of indomethacin

作者: Pen-Yuan Lin , Fu-An Chen , An-Bang Wu , Su-Hui Chao , Yu-Tang Peng

DOI: 10.1007/S13738-016-0895-X

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摘要: In a photochemical chamber, sample of 27.9 mM indomethacin (IN) in methanol was exposed to Philips 400-W UV lamp for 5 days normal atmosphere. Four photoproducts were separated using high-performance liquid chromatography, and their structures elucidated by various spectroscopic methods, including chromatography–electrospray ionization–mass spectrometry. A reaction scheme IN is proposed: The routes occur mainly via esterification decarboxylation, followed oxidation with singlet oxygen produce an aldehyde. β-hydroxy-γ-lactone also formed through [2 + 2] cycloaddition, its structure confirmed single-crystal X-ray diffraction.

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