The photochemistry of indomethacin
作者： Alan C. Weedon , David F. Wong
DOI: 10.1016/1010-6030(91)85071-N
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摘要: Abstract The photochemistry of the anti-inflammatory drug Indomethacin (N-(para-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid (1) was investigated. Unlike previously examined N-carbonyl-substituted indoles, which undergo photo-Fries rearrangement and photocycloaddition to alkenes, yields products derived from photochemical decarboxylation acetic side chain. also exhibits unusual long wavelength fluorescence is ascribed a charge transfer singlet excited state.
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