Argon laser-induced arterial photothrombosis. Characterization and possible application to therapy of arteriovenous malformations.

摘要: The common carotid, femoral, and middle cerebral arteries in the rat have been occluded thrombotically by means of a rose bengal dye-sensitized photochemical reaction initiated vascular endothelium 514.5-nm beam an argon laser, focused for maximum excitation efficiency photosensitizer according to derived criterion. total energy required vessel occlusion was approximately 1 joule (J) artery 140 180 J femoral carotid arteries. At fluences (energy deposited per unit area) 3.5 kJ/sq cm 35 larger arteries, observed within 3 minutes. thrombus consisted entirely aggregated platelets; thrombi were composed platelet aggregates groups red blood cells interspersed matrix coagulum. Vessels irradiated similarly absence dye displayed no morphological or functional damage. Because is mediated electronic-state transitions, process photothrombosis (as opposed photocoagulation) can be vessels with high flow rates without requirement increased temperature. photothrombotic technique may useful treatment arteriovenous malformations owing its significant enhancement permanency occlusion.