Specific Roles of JAKs and STAT3 in Functions of Neural Stem Cells and Committed Neuronal Progenitors during Ethanol-Induced Neurodegeneration.
作者： G. N. Zyuz’kov , L. A. Miroshnichenko , T. Yu. Polyakova , L. A. Stavrova , E. V. Simanina
DOI: 10.1007/S10517-020-04708-W
关键词:
摘要: Peculiar roles of JAKs and STAT3 in realization growth potential various types progenitor cells neural tissue were examined during ethanol-induced neurodegeneration modeled both vitro vivo. During action C2H5OH, these signal molecules exerted the opposite effects on mitotic activity multipotent stem committed progenitors (the clonogenic PSA-NCAM+ cells). The inhibitors down-regulated rate cell division (proliferative activity) but up-regulated such progenitors. A long-term vivo exposure mice to ethanol inversed determination proliferative status eliminated involvement functional control over neurons. data attest much promise treatment CNS diseases as remedies that stimulate
springer.com
sci-hub.se 参考文章(15)
G. N. Zyuz’kov, M. G. Danilets, A. A. Ligacheva, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, A. V. Chaikovskii, E. S. Trofimova, M. Yu. Minakova, V. V. Udut, A. M. Dygai, PI3K, MAPK EPK1/2 and p38 are Involved in the Realization of Growth Potential of Mesenchymal Progenitor Cells under the Infl uence of Basic Fibroblast Growth Factor Bulletin of Experimental Biology and Medicine. ,vol. 157, pp. 436- 439 ,(2014) , 10.1007/S10517-014-2584-Z
Gerhard P. Jordaan, Robin Emsley, Alcohol-induced psychotic disorder: a review Metabolic Brain Disease. ,vol. 29, pp. 231- 243 ,(2014) , 10.1007/S11011-013-9457-4
Masaru Tateno, Wataru Ukai, Megumi Yamamoto, Eri Hashimoto, Hiroshi Ikeda, Toshikazu Saito, The effect of ethanol on cell fate determination of neural stem cells. Alcoholism: Clinical and Experimental Research. ,vol. 29, ,(2005) , 10.1097/01.ALC.0000190658.56149.D4
Tatsunori Seki, Expression patterns of immature neuronal markers PSA‐NCAM, CRMP‐4 and NeuroD in the hippocampus of young adult and aged rodents Journal of Neuroscience Research. ,vol. 70, pp. 327- 334 ,(2002) , 10.1002/JNR.10387
Kimberly Nixon, Alcohol and adult neurogenesis: roles in neurodegeneration and recovery in chronic alcoholism. Hippocampus. ,vol. 16, pp. 287- 295 ,(2006) , 10.1002/HIPO.20162
Jing-Yu Yang, Xue Xue, Hua Tian, Xiao-Xiao Wang, Ying-Xu Dong, Fang Wang, Ya-Nan Zhao, Xue-Chun Yao, Wei Cui, Chun-Fu Wu, Role of microglia in ethanol-induced neurodegenerative disease: Pathological and behavioral dysfunction at different developmental stages Pharmacology & Therapeutics. ,vol. 144, pp. 321- 337 ,(2014) , 10.1016/J.PHARMTHERA.2014.07.002
Fulton T. Crews, Kim Nixon, Alcohol, neural stem cells, and adult neurogenesis Alcohol Research & Health. ,vol. 27, pp. 197- 204 ,(2003)
Maria Nilsson, Charlotte Sonne, [Diagnostics and treatment of Wernicke-Korsakoff syndrome patients with an alcohol abuse]. Ugeskrift for Læger. ,vol. 175, pp. 942- 944 ,(2013)
John C.M. Brust, Acute withdrawal: diagnosis and treatment. Handbook of Clinical Neurology. ,vol. 125, pp. 123- 131 ,(2014) , 10.1016/B978-0-444-62619-6.00008-2
Zhdanov Vadim Vadimovich, Danilets Marina Grigorevna, Zyuzkov Gleb Nikolaevich, Miroshnichenko Larisa Arkadevna, Udut Elena Vladimirovna, Dygaj Aleksandr Mikhajlovich, TISSUE REGENERATION STIMULATING AGENT ,(2016)