Bioactive phenazines from an earwig-associated Streptomyces sp.
作者： Hao HAN , Zhi-Kai GUO , Bo ZHANG , Mei ZHANG , Jing SHI
DOI: 10.1016/S1875-5364(19)30055-X
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摘要: Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures these compounds determined by extensive analyses NMR, high resolution mass spectroscopic data, as well single-crystal X-ray diffraction measurement. Sequencing and analysis genome data allowed us to identify gene cluster (spz) propose a biosynthetic pathway for compounds. Additionally, 1-5 exhibited moderate inhibitory activity against acetylcholinesterase (AChE), compound 3 showed antimicrobial activities Micrococcus luteus.
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