A novel comby scaffold with improved mechanical strength for bone tissue engineering
作者： Hongxia Zhao , Weihuan Liang
DOI: 10.1016/J.MATLET.2017.02.059
关键词:
摘要: Abstract Porous scaffold is an integral part of bone tissue engineering. However, low mechanical strength a major challenge. A biomimetic comby was designed to get improvement in this paper. Fabrication involved first creating pore-forming mold by using three-dimensional printing (3DP), which cast into chitosan/nano-hydroxyapatite (CS/nHA) powders create inverse mold. The sacrificial and one were then pressed cold isostatic pressing as whole order enhance the strength. Finally, wax template removed, resulting with honeycomb geometry. Compression tests carried out evaluate scaffold. behaviors responses preosteoblast cells on studied well. high porosity found display improved compressive (1.62 ± 0.22 MPa) Young’s modulus (110 ± 22 Mpa) approaching values cancellous bone. Moreover, MC3T3-E1 exhibited good proliferation had great application potential This novel structural bionic approach would offer some new ideas design fabrication porous scaffolds for
elsevier.com
sci-hub.se 参考文章(12)
Agata Przekora, Krzysztof Palka, Grazyna Ginalska, Biomedical potential of chitosan/HA and chitosan/β-1,3-glucan/HA biomaterials as scaffolds for bone regeneration--A comparative study. Materials Science and Engineering: C. ,vol. 58, pp. 891- 899 ,(2016) , 10.1016/J.MSEC.2015.09.046
Francesca Scalera, Carola Esposito Corcione, Francesco Montagna, Alessandro Sannino, Alfonso Maffezzoli, Development and characterization of UV curable epoxy/hydroxyapatite suspensions for stereolithography applied to bone tissue engineering Ceramics International. ,vol. 40, pp. 15455- 15462 ,(2014) , 10.1016/J.CERAMINT.2014.06.117
Hongxia Zhao, Hua Jin, Jiye Cai, Preparation and characterization of nano-hydroxyapatite/chitosan composite with enhanced compressive strength by urease-catalyzed method Materials Letters. ,vol. 116, pp. 293- 295 ,(2014) , 10.1016/J.MATLET.2013.05.082
Ana Marina Ferreira, Piergiorgio Gentile, Valeria Chiono, Gianluca Ciardelli, Collagen for bone tissue regeneration. Acta Biomaterialia. ,vol. 8, pp. 3191- 3200 ,(2012) , 10.1016/J.ACTBIO.2012.06.014
Susmita Bose, Sahar Vahabzadeh, Amit Bandyopadhyay, Bone tissue engineering using 3D printing Materials Today. ,vol. 16, pp. 496- 504 ,(2013) , 10.1016/J.MATTOD.2013.11.017
Lihua Li, Bo Li, Mingyan Zhao, Shan Ding, Changren Zhou, Single-step mineralization of woodpile chitosan scaffolds with improved cell compatibility. Journal of Biomedical Materials Research Part B. ,vol. 98, pp. 230- 237 ,(2011) , 10.1002/JBM.B.31811
Johanna Melke, Swati Midha, Sourabh Ghosh, Keita Ito, Sandra Hofmann, Silk fibroin as biomaterial for bone tissue engineering Acta Biomaterialia. ,vol. 31, pp. 1- 16 ,(2016) , 10.1016/J.ACTBIO.2015.09.005
Hai Wang, Gui Wu, Jing Zhang, Kui Zhou, Bo Yin, Xinlin Su, Guixing Qiu, Guang Yang, Xianglin Zhang, Gang Zhou, Zhihong Wu, Osteogenic effect of controlled released rhBMP-2 in 3D printed porous hydroxyapatite scaffold Colloids and Surfaces B: Biointerfaces. ,vol. 141, pp. 491- 498 ,(2016) , 10.1016/J.COLSURFB.2016.02.007
Alok Kumar, Sourav Mandal, Srimanta Barui, Ramakrishna Vasireddi, Uwe Gbureck, Michael Gelinsky, Bikramjit Basu, Low temperature additive manufacturing of three dimensional scaffolds for bone-tissue engineering applications: Processing related challenges and property assessment Materials Science & Engineering R-reports. ,vol. 103, pp. 1- 39 ,(2016) , 10.1016/J.MSER.2016.01.001
Dimitris Tsiourvas, Andreas Sapalidis, Triantafillos Papadopoulos, Hydroxyapatite/chitosan-based porous three-dimensional scaffolds with complex geometries Materials today communications. ,vol. 7, pp. 59- 66 ,(2016) , 10.1016/J.MTCOMM.2016.03.006