作者: Andrea Giustina , Ariel Barkan , Albert Beckers , Nienke Biermasz , Beverly M K Biller
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摘要: Objective The aim of the Acromegaly Consensus Group was to revise and update consensus on diagnosis treatment acromegaly comorbidities last published in 2013. Participants Group, convened by 11 Steering Committee members, consisted 45 experts medical surgical management acromegaly. authors received no corporate funding or remuneration. Evidence This evidence-based developed using Grading Recommendations, Assessment, Development, Evaluation (GRADE) system describe both strength recommendations quality evidence following critical discussion current literature comorbidities. process participants conducted comprehensive searches for English-language papers selected topics, reviewed brief presentations each topic, discussed practice breakout groups. were based all discussions. Members Scientific graded supporting GRADE system. Conclusions Evidence-based approach address important clinical issues regarding multidisciplinary acromegaly-related cardiovascular, endocrine, metabolic, oncologic comorbidities, sleep apnea, bone joint disorders their sequelae, as well effects life mortality.