Immunity and inflammation in the pathogenesis of atherosclerosis

摘要: Summary This paper reviews and discusses the evidence that immune mechanisms inflammation may be involved in pathogenesis of atherosclerosis ischaemic vascular disease (I.V.D.). Thrombosis, lipid imbibition arteritis are existing theories origin atherosclerosis. The latter two can combined, as increase endothelial permeability due to lead increased entry. development rabbit inhibited by anti-inflammatory immunosuppressive durgs. Arteritis produced experimentally complex (serum sickness), when combined with feeding leads rapidly occurrence immune-complex induced man is suggested finding levels milk antibodies patients myocardial infarction; has been obtained for absorption undigested dietary proteins. An incidence allergy tobacco protein was found smokers I.V.D. possibility abnormalities platelet red cell behaviour complexes considered. action on platelets promote thrombosis. Hyperlipidaemia antigenic challenge certain autoantibodies. Autoantibodies arterial tissues have involvement these cellmediated atherosclerotic plaque discussed. Inflammation produce a self perpetuating process which deposits cause further