Is There a Role for Immunotherapy in Osteosarcoma

摘要: With the introduction of effective systemic chemotherapy, prognosis for patients with osteosarcoma has improved dramatically. Estimates overall survival prior to 1975 ranged from 5 20%, even localized disease extremity treated amputation. The majority these eventually developed pulmonary metastases and succumbed their disease. chemotherapy dramatically outcome disease, but not altered metastatic Moreover, there been little, if any, improvement in outcomes since mid-1980s. This led investigation other treatment approaches, including immunotherapy. Coincident initial development were early attempts at These met little success. Subsequent approaches harnessing immune system have yielded more encouraging results. chapter will review various highlighting role that immunotherapy might play multi-modality osteosarcoma.