Osteosarcoma

摘要: The most prevalent primary malignant bone tumor affecting children and adolescents is osteosarcoma. Osteosarcoma characterized by the formation of immature or osteoid tissue neoplastic cells. They arise predominantly in long bones, occasionally axial seldom soft tissues. Patients with osteosarcoma are currently treated preoperative (neoadjuvant) chemotherapy followed resection, further postoperative chemotherapy. Wide margin resection often necessary leave large defects. These defective bones must be reconstructed repaired using appropriate materials methods to restore function structure. Currently, autograft, allograft, prosthetic implant, a combination used for defect reconstruction. Despite available options, reconstruction defects improvement survival rates still challenging. Tissue engineering regenerative medicine (TERM) may promising alternative strategies regenerate change conventional treatment patients TERM form scaffolds, healing promotive factors, stem cells could designed useful regeneration also delivery anti-cancer therapeutic agents. Combining approaches immunotherapy, chemoimmunotherapy, radioimmunotherapy, gene therapy together advances diagnostic procedures palliative results curative achievements future. This review comprehensively discusses current challenges, possible strategies, future directions managing