Vaccinology: time to change the paradigm?

摘要: The existing vaccine paradigm assumes that vaccines only protect against the target infection, effective reduce mortality corresponding to infection's share of total mortality, and effects are similar for males females. However, epidemiological research has generated observations contradict these assumptions suggest have important non-specific on overall health in populations. These include several live incidence all-cause vaccinated compared with unvaccinated populations far more than can be explained by protection infections, non-live associated increased In this Personal View we describe current contradictions define six emerging principles might explain them. First, enhance resistance towards unrelated infections. Second, susceptibility girls Third, most recently administered vaccination strongest effects. Fourth, combinations given together variable Fifth, vaccinating children presence maternal immunity enhances beneficial reduces mortality. Finally, interact other co-administered interventions, example vitamin A supplementation. potential implications child substantial. For example, if BCG was at birth, higher measles coverage could obtained, diphtheria, tetanus, pertussis-containing were not or after vaccine, strain best used consistently, then considerably lower. Pursuing improve our understanding use globally.