Chapter 28 – Personalized Epigenetic Therapy—Chemosensitivity Testing
作者： Benet Pera , Leandro Cerchietti
DOI: 10.1016/B978-0-12-800206-3.00028-8
关键词:
摘要: Decreased expression of tumor suppressor genes and checkpoints by epigenetic mechanisms, such as DNA hypermethylation, is used malignant cells to alter the specific pathways that will allow them sustain oncogenic state survive extrinsic changes those imposed chemotherapy agents. Reactivation agents can reprogram a more benign phenotype while making susceptible Here, using aggressive lymphomas model, we discuss concept on how hypomethylating drugs histone deacetylase inhibitors be sensitize refractory tumors in clinical setting.
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sci-hub.se 参考文章(40)
V. Diehl, A. Lister, J.A. Radford, D. Ma, P. Johnson, A. Engert, F. Reyes, C. Haioun, H. Tilly, R. Capdeville, B. Coiffier, N. Ketterer, M. Feuring Buske, Rituximab (Anti-CD20 Monoclonal Antibody) for the Treatment of Patients With Relapsing or Refractory Aggressive Lymphoma: A Multicenter Phase II Study Blood. ,vol. 92, pp. 1927- 1932 ,(1998) , 10.1182/BLOOD.V92.6.1927
Hideaki Ijichi, Motoyuki Otsuka, Keisuke Tateishi, Tsuneo Ikenoue, Takayuki Kawakami, Fumihiko Kanai, Yoshihiro Arakawa, Naohiko Seki, Kiyoshi Shimizu, Kohei Miyazono, Takao Kawabe, Masao Omata, Smad4-independent regulation of p21/WAF1 by transforming growth factor- β Oncogene. ,vol. 23, pp. 1043- 1051 ,(2004) , 10.1038/SJ.ONC.1207222
Juan I. Young, John M. Sedivy, James R. Smith, Telomerase Expression in Normal Human Fibroblasts Stabilizes DNA 5-Methylcytosine Transferase I Journal of Biological Chemistry. ,vol. 278, pp. 19904- 19908 ,(2003) , 10.1074/JBC.M301685200
Teresa Palomero, Lucile Couronné, Hossein Khiabanian, Mi-Yeon Kim, Alberto Ambesi-Impiombato, Arianne Perez-Garcia, Zachary Carpenter, Francesco Abate, Maddalena Allegretta, J Erika Haydu, Xiaoyu Jiang, Izidore S Lossos, Concha Nicolas, Milagros Balbin, Christian Bastard, Govind Bhagat, Miguel A Piris, Elias Campo, Olivier A Bernard, Raul Rabadan, Adolfo A Ferrando, None, Recurrent mutations in epigenetic regulators, rhoa and fyn kinase in peripheral t-cell lymphomas Nature Genetics. ,vol. 46, pp. 166- 170 ,(2014) , 10.1038/NG.2873
Hannah Farmer, Nuala McCabe, Christopher J. Lord, Andrew N. J. Tutt, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa, Krystyna J. Dillon, Ian Hickson, Charlotte Knights, Niall M. B. Martin, Stephen P. Jackson, Graeme C. M. Smith, Alan Ashworth, Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature. ,vol. 434, pp. 917- 921 ,(2005) , 10.1038/NATURE03445
Rita Shaknovich, Ari Melnick, Epigenetics and B-cell Lymphoma Current Opinion in Hematology. ,vol. 18, pp. 293- 299 ,(2011) , 10.1097/MOH.0B013E32834788CF
Yanwen Jiang, Katerina Hatzi, Rita Shaknovich, Mechanisms of epigenetic deregulation in lymphoid neoplasms Blood. ,vol. 121, pp. 4271- 4279 ,(2013) , 10.1182/BLOOD-2012-12-451799
Martin Levitt, John C. Marsh, Ronald C. Deconti, Malcolm S. Mitchell, Roland T. Skeel, Leonard R. Farber, Joseph R. Bertino, Combination sequential chemotherapy in advanced reticulum cell sarcoma Cancer. ,vol. 29, pp. 630- 636 ,(1972) , 10.1002/1097-0142(197203)29:3<630::AID-CNCR2820290316>3.0.CO;2-Q
ZW Quan, JN Yue, JY Li, YY Qin, RS Guo, SG Li, None, Somatostatin elevates topoisomerase II alpha and enhances the cytotoxic effect of doxorubicin on gallbladder cancer cells. Chemotherapy. ,vol. 54, pp. 431- 437 ,(2008) , 10.1159/000158662
Xuefeng Liu, Virginie Ory, Sandra Chapman, Hang Yuan, Chris Albanese, Bhaskar Kallakury, Olga A. Timofeeva, Caitlin Nealon, Aleksandra Dakic, Vera Simic, Bassem R. Haddad, Johng S. Rhim, Anatoly Dritschilo, Anna Riegel, Alison McBride, Richard Schlegel, ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells The American Journal of Pathology. ,vol. 180, pp. 599- 607 ,(2012) , 10.1016/J.AJPATH.2011.10.036