Regulation of thymus-independent responses: unresponsiveness to a second challenge of TNP-Ficoll is mediated by hapten-specific antibodies.

摘要: CBA mice immunized with the TI-2 antigen TNP-Ficoll are unresponsive to a second challenge of same antigen. In addition, spleen cells from fail respond any dose in vitro. This hapten-specific state is T cell independent and due IgM-mediated inhibition B triggering. The mechanism inhibition, although unknown, unlikely be masking. vitro responses TI-1 TNP-LPS not inhibited by concentrations anti-TNP antibody, which completely suppress TNP-Ficoll.