Wnt Signaling in vascular eye diseases.
作者： Zhongxiao Wang , Chi-Hsiu Liu , Shuo Huang , Jing Chen
DOI: 10.1016/J.PRETEYERES.2018.11.008
关键词:
摘要: The Wnt signaling pathway plays a pivotal role in vascular morphogenesis various organs including the eye. ligands and receptors are key regulators of ocular angiogenesis both during eye development diseases. participates regulating multiple beds regression hyaloid vessels, structured layers vasculature retina. Loss-of-function mutations components cause rare genetic diseases humans such as Norrie disease, familial exudative vitreoretinopathy (FEVR) with defective vasculature. On other hand, experimental studies more prevalent diseases, wet age-related macular degeneration (AMD), diabetic retinopathy (DR), prematurity (ROP), corneal neovascularization, suggest that aberrantly increased is one causations for pathological indicating potential modulating to ameliorate This review recapitulates roles pharmaceutical approaches targeting treatment options.
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