Serum ferritin levels and the development of metabolic syndrome and its components: a 6.5-year follow-up study

作者: Päivi Hämäläinen , Juha Saltevo , Hannu Kautiainen , Pekka Mäntyselkä , Mauno Vanhala

DOI: 10.1186/1758-5996-6-114

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摘要: The aim of this study was to investigate the relationship between changes in serum ferritin concentrations and development metabolic syndrome (MetS) its components over a 6.5 year follow-up period Finnish adults. Adults born Pieksamaki, Finland, 1942, 1947, 1952, 1957, 1962 (n = 1294) were invited health checkups 1997 1998 2003 2004. All required variables for both available from 691 (53%) subjects (289 men 402 women). MetS defined by National Cholesterol Education Program criteria. During 6.5-year period, 122 (18%) developed incident cases MetS. Increases levels significantly higher women with compared without (p 0.04, p 0.03). Also, increased less whom criteria resolved during 0.01). lower glucose criterion resolved, waist 0.01 <0.001, respectively). Serum decreased more triglyceride There clear significant correlation change level circumference <0.01). In addition, correlations plasma as well strongly positive <0.001). negative high density cholesterol women. 6,5 year are associated Whereas, increases same timeframe resolution hypertriglyceridemia hyperglycemia positively correlated

参考文章(40)
Ki-Dong Yoo, Seung-Hyun Ko, Ji-Eun Park, Yu-Bae Ahn, Hyeon Woo Yim, Won-Chul Lee, Yong-Moon Park, High serum ferritin levels are associated with metabolic risk factors in non-obese Korean young adults: Korean National Health and Nutrition Examination Survey (KNHANES) IV. Clinical Endocrinology. ,vol. 77, pp. 233- 240 ,(2012) , 10.1111/J.1365-2265.2011.04248.X
Tomás Meroño, Leonardo Gómez Rosso, Patricia Sorroche, Laura Boero, Jorge Arbelbide, Fernando Brites, High risk of cardiovascular disease in iron overload patients European Journal of Clinical Investigation. ,vol. 41, pp. 479- 486 ,(2011) , 10.1111/J.1365-2362.2010.02429.X
Anja Schienkiewitz, Matthias B Schulze, Kurt Hoffmann, Anja Kroke, Heiner Boeing, Body mass index history and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. The American Journal of Clinical Nutrition. ,vol. 84, pp. 427- 433 ,(2006) , 10.1093/AJCN/84.1.427
S. K. Park, J.-H. Ryoo, M.-G. Kim, J.-Y. Shin, Association of Serum Ferritin and the Development of Metabolic Syndrome in Middle-Aged Korean Men: A 5-year follow-up study Diabetes Care. ,vol. 35, pp. 2521- 2526 ,(2012) , 10.2337/DC12-0543
Robert H Eckel, KGMM Alberti, Scott M Grundy, Paul Z Zimmet, The metabolic syndrome The Lancet. ,vol. 365, pp. 1415- 1428 ,(2005) , 10.1016/S0140-6736(09)61794-3
K. F. Petersen, S. Dufour, D. B. Savage, S. Bilz, G. Solomon, S. Yonemitsu, G. W. Cline, D. Befroy, L. Zemany, B. B. Kahn, X. Papademetris, D. L. Rothman, G. I. Shulman, The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 12587- 12594 ,(2007) , 10.1073/PNAS.0705408104
Nicola Martinelli, Michela Traglia, Natascia Campostrini, Ginevra Biino, Michela Corbella, Cinzia Sala, Fabiana Busti, Corrado Masciullo, Daniele Manna, Sara Previtali, Annalisa Castagna, Giorgio Pistis, Oliviero Olivieri, Daniela Toniolo, Clara Camaschella, Domenico Girelli, Increased Serum Hepcidin Levels in Subjects with the Metabolic Syndrome: A Population Study PLoS ONE. ,vol. 7, pp. e48250- ,(2012) , 10.1371/JOURNAL.PONE.0048250
James D. Cook, Carol H. Flowers, Barry S. Skikne, The quantitative assessment of body iron. Blood. ,vol. 101, pp. 3359- 3364 ,(2003) , 10.1182/BLOOD-2002-10-3071
Jean-Pierre Després, Isabelle Lemieux, Abdominal obesity and metabolic syndrome Nature. ,vol. 444, pp. 881- 887 ,(2006) , 10.1038/NATURE05488