Hepatitis A outbreak associated with a revolving sushi bar in Chiba, Japan: Application of molecular epidemiology
作者： Atsuko Tominaga , Tatsuo Kanda , Taro Akiike , Hiroshi Komoda , Kenji Ito
DOI: 10.1111/J.1872-034X.2012.00988.X
关键词:
摘要: Aim: The number of hepatitis A cases in Japan as well other developed countries has been progressively decreasing during the last several years. There is no universal vaccination program Japan, and a virus (HAV) epidemic not unlikely. In 2011, outbreak associated with revolving sushi bar occurred Chiba, Japan. We aimed to analyze this outbreak. Methods: Twenty-seven patients were admitted National Hospital Organization Chiba Medical Center. Molecular epidemiologic investigations conducted. Results: Twenty-six 27 had gone same bar, then clinical symptoms appeared. HAV RNA was detected by reverse transcription polymerase chain reaction 23 (85.1%) whose sera tested positive for anti-HAV immunoglobulin M. All isolates from clustered within subgenotype IA, displaying 100% sequence homology each 232 bp all patients. belong IA-1 sublineage, which endemic Japan. Conclusion: outbreak, molecular epidemiological proved useful.
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