Improvement of Obesity and Dyslipidemic Activity of Amomum tsao-ko in C57BL/6 Mice Fed a High-Carbohydrate Diet.

摘要: Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim this study was to investigate effect an ethanol extract (EAT) on obesity and hyperlipidemia C57BL/6 mice fed high-carbohydrate diet (HCD). First, were divided into five groups (n = 6/group) as follows: normal diet, HCD, HCD+EAT (100, 200, 400 mg/kg/day), which orally administered with EAT daily 84 days. Using microcomputed tomography (micro-CT) analysis, we inhibited not only body-weight gain, but also visceral fat subcutaneous accumulation. Histological analysis confirmed decreased size tissues. consistently improved various indices, including plasma levels total cholesterol (TC), triglyceride (TG), low-density lipoprotein, high-density atherogenic index, cardiac risk factors, are related dyslipidemia—a major factor heart disease. contents TC TG, well lipid droplets HCD-induced hepatic accumulation liver tissue, suppressed by EAT. Taken together, these findings suggest possibility developing therapeutic agent improving hyperlipidemia.